Articles

Newsletter Spring 2021

 
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A Note from the CEO

 

 

Thomas Seoh
Chief Executive Officer of Kinexum
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Welcome to the Spring 2021 edition of Kinexions! Zan talks about Michael Zemel's thought-provoking piece on dietary guidelines in his Chairman’s Note. Other articles in this issue include an interview of Alex Zhavoronkov, CEO of InSilico Medicine, a leader in the application of AI to drug discovery and healthy longevity (almost makes me want to rush out to buy a packet of cigarettes in Eastern Europe - read the piece to get the reference). Also, our Kinexum Associates Brontë Jenkins and EJ Abass summarize recent webinars that have gotten sizable exposure in recent months.  In fact, among the Mitochondria, Wow or Yeow?!, and Exercise webinars in January and February, we had a total of over 2,000 global registrants.  Hopefully, this reflects the growing value of Kinexum and Kitalys Institute webinars for those interested...
 

 

 

 

 

Dietary Guidelines for Americans 2020-2025: We're Not There Yet...

 

 

Michael Zemel, PhD
Chief Scientific Officer of Kinexum
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The new Dietary Guidelines for Americans 2020-2025 (DGA) were recently released December 29, 2020 (see here), and while the document contains a number of appropriate recommendations, it is largely a disappointment. Some background is in order for those not familiar with this process.  The DGA were first issued in 1980 in recognition of the crucial role that diet and nutrition have in what the government rightly perceived as an alarming increase in the risk of chronic disease...

 

 

 

 

Conference Recap: CVCT's Increasing Healthspan Session

 

 

Elijah "EJ" Abass
Kinexum Associate
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During the 17th Cardiovascular Clinical Trialist (CVCT) conference held virtually in December 2020, Kinexum founder and Executive Chairman, Dr. Alexander Fleming, along with co-moderator University of Melbourne Professor of Aged Care Dr. Andrea Meier, led an interdisciplinary session entitled “Increasing Healthspan: The Next Frontier for Clinical Trialists." CVCT connects leading clinical trialists in cardiovascular medicine with high level regulators from the FDA, EMA and other agencies, industry, patient groups, and other stakeholders...

 

 

 

 

Webinar Recap: Wow or Yeow?! FDA Outlook for 2021 and Beyond
by Brontë Jenkins, Kinexum Associate

 

 

 

At Kinexum’s January 29th public webinar entitled, “Wow or Yeow?! FDA Outlook for 2021 or Beyond,” an all-star panel of regulatory thought leaders led by Dr. Alexander Fleming, Founder and Executive Chairman of Kinexum, looked back at a turbulent year for the United States Food and Drug Administration (FDA) and anticipated what the Agency will do in 2021. The first edition of Wow or Yeow aired the day before the inauguration of Donald Trump in January 2017 and unpacked what lay ahead for FDA in a new era...
 

 


 

 

A Note from the Chairman

 

 

G. Alexander "Zan" Fleming
Founder & Chairman of Kinexum
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I am glad that my good friend and esteemed colleague, Michael Zemel, has written for this edition of Kinexions a concise and compelling critique of the U.S. Department of Agriculture’s new Dietary Guidelines for Americans.  The long series of guidelines put forth by USDA and FDA related to food and nutritional products have always been imperfect and often controversial.  More than ever, we do need science-based food and nutrition policies from federal agencies and credible organizations like the National Institutes of Health and the National Academy of Sciences.  How all that gets done and conveyed to the American people is complicated and a never-ending challenge. Michael and other colleagues at Kinexum and the Kitalys Institute are not just interested in the science and policy of nutrition, but also physical exercise,... 
 

 

 


 

 

Interview with Dr. Alex Zhavoronkov

 

 

Alex Zhavoronkov, PhD
Founder & CEO of InSilico Medicine
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Dr. Zhavoronkov, is the founder and CEO of InSilico Medicine, a global leader in the next-generation artificial intelligence technologies for drug discovery, biomarker development, and aging research. At InSilico, he pioneered the applications of generative adversarial networks and reinforcement learning techniques for generating the novel molecular structures with the desired properties and generation of synthetic biological and patient data... (See rest of Dr. Zhavoronkov's bio at the bottom of his piece).

 

 

 

 

Webinar Recap: Mitochondria, Aging, and Health

 

 

Elisabeth Brontë Jenkins
Kinexum Associate
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At the January 8th, 2020 virtual webinar hosted by the Kitalys Institute and Kinexum entitled, “Mitochondria, Aging, and Health,” an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the interconnected nature of these three topics. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysfunction and sequelae (e.g., inflammaging) lie at the heart of the complex of chronic diseases of aging called “metabesity”...

 

 


 

 

Webinar Recap: Why and How Can Exercise Slow the Aging Process?
by EJ Abass, Kinexum Associate

 

 

 

The February 26, 2021 Kitalys Institute public webinar entitled “Why and How Can Exercise Slow the Aging Process?”, moderated by Dr. Joan Mannick, Head of Research and Development at Life Biosciences, examined the basis of exercise’s effects on aging from both an evolutionary perspective (the why), and a molecular perspective (the how). Dr. Daniel Lieberman, Professor of Human Evolutionary Biology at Harvard University, researches how and why the human body operates the way it does through the lens of evolution...