Newsletter Winter 2021






A Note from the CEO


Welcome to the Winter 2021 edition of KinexionsMy customary message would highlight the contents of this very full (and for me fascinating) Winter 2021 edition of Kinexions, Kinexum’s quarterly newsletter.  Instead, I want to ruminate on the tumultuous 2020 that is coming to a close...




How does “Operation Warp Speed” vaccine development compare to “regular” vaccine development?


With the clamor for an effective vaccine to quell the COVID-19 pandemic, it is timely to discuss the vaccine development process.  Many people are concerned that the “Operation Warp Speed Accelerated Vaccine Process” will leave out important steps in the development process, allowing for an “unsafe” and/or “non-efficacious” vaccine to gain approval...




GSA Pre-Conference Workshop Q&A



Kinexum hosted a Pre-Conference Workshop to the Gerontological Society of America 2020 Virtual Annual Meeting on October 27, 2020. The public, law and policy makers, and even those in the field of aging and aging care are not fully aware that biological aging is now being delayed, even reversed, and can prevent or delay chronic diseases of aging...



FDA Update

Thank you, FDA.

During this season, as we give thanks around the holidays, we should also be thankful for FDA career staff who perform their jobs at relatively low pay, in under-resourced organizations, and with the heavy burdens of government bureaucracy. Despite these obstacles, some skilled individuals are able to rise above the immediate issues and see the big picture regarding the mission of the U.S. Food & Drug Administration (FDA)...



A Note from the Chairman

We often draw upon Charles Dickens around Christmas time and even Chanukah. One of Dickens’ most famous work, A Christmas Carol, is about far more than Christmas promoting universal principles of compassion and social justice. Publication of the book in 1844 resulted in an unprecedented spike in Christmastime charitable donations in the United Kingdom, and that tradition of giving has continued to this very day...




My Adventures with Growth Hormone

After internship and residency in internal medicine at Washington University in St. Louis, my endocrinology training began at the Interinstitute Endocrine Training Program at NIH.  The program was remarkable in several ways. First, there were no interns or residents at NIH, so endocrine fellows directly managed all endocrine patients, including night call, providing an intense clinical experience...



Interview with Dr. Nir Barzilai

Dr. Barzilai is a chaired Professor of Medicine and Genetics, and Director of the Nathan Shock Center of Excellence in the Biology of Aging, the biggest center in the world to study the biology of aging. He is the recipient of an NIH Merit Award aiming to extend the healthy life span in rodents by biological interventions, as well as numerous other prestigious awards, including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Additionally, Dr. Barzilai is a Co-Principal Investigator of Targeting Aging with Metformin (TAME) trial, which will examine whether metformin, a very common generic drug for diabetes, may be able to delay the onset of a basket of chronic diseases and conditions of aging. Dr. Barzilai is a founder of CohBar, Inc. (now a public company), and Chief Medical Advisor for Life Biosciences. He is a co-scientific director of the American Federation for Aging Research (AFAR), and serves on both the board of AFAR and CohBar...




Upcoming Webinars

Mitochondria, Aging, and Health



Mitochondria are commonly referred to as the powerhouses of cells because they create the energy necessary for cell function; however, these organelles do much more than that within our bodies. At Targeting Metabesity 2020 this past October, an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the key role of mitochondria in aging and health. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysregulation and sequelae, such as inflammaging, are at the heart of the complex of chronic diseases of aging called “metabesity.” Join our panel for an updated dive into one of the major drivers of aging and health. For more information and to register, see here.

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Wow or Yeow?! FDA Outlook for 2021 and Beyond